NanoBiosensors and BioDevices Laboratory
Prof. Dr. Gorachand Dutta
Assistant Professor Grade-I, School of Medical Science and Technology
Indian Institute of Technology Kharagpur
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NanoBiosensors and Biodevices Laboratory • IIT Kharagpur
Indian Institute of Technology Kharagpur
About PI
Dr. Gorachand Dutta is an Assistant Professor at the School of Medical Science and Technology, IIT Kharagpur. He obtained his M.Sc. degree in Chemistry from IIT Guwahati and completed his PhD in Biosensors and Electrochemistry from Pusan National University, South Korea.
His doctoral research focused on developing advanced electrochemical sensors. Following his PhD, he pursued postdoctoral research at Michigan State University, USA, and the University of Bath, United Kingdom.
During his research tenure in the USA and UK, he developed innovative enzyme-free disposable immunosensor chips using micropatterned electrodes and wash-free detection systems, enabling mobile-phone-based point-of-care diagnostic platforms for infectious and metabolic diseases.
His expertise spans label-free multichannel electrochemical biosensors, electronically addressable biosensor arrays, aptamer and DNA-based sensors, and advanced surface bio-functionalization strategies.
Research Focus Areas
Lab-on-PCB Devices
Low-cost integrated biosensor devices using printed circuit boards.Immunosensors
Enzyme-based immunosensor and ELISA platform development.Ultra-Sensitive Detection
Magnetic bead assays, nanoparticles, CNTs and dendrimer-assisted biosensors.Lab-on-a-Chip Systems
Microfluidic biomedical diagnostic devices for rapid healthcare testing.Bio-Nanotechnology
Nanomaterials and smart systems for targeted drug delivery.Self-Powered Biosensors
Integration of biosensors with fuel cells for autonomous biodevices.Awards & Editorial Activities
- Pusan National University Research Fellowship
- BK-21 Fellowship, South Korea
- Faculty Excellence Awards
- Editorial Board Member – Scientific Reports (Nature Portfolio)
- Editorial Board Member – Electrochemical Sensors
- Guest Editor – Micromachines
- Guest Editor – Frontiers in Chemistry
- Guest Editor – Frontiers in Sensors
NanoBiosensors & BioDevices Laboratory
School of Medical Science and Technology, Indian Institute of Technology Kharagpur
Lab Overview
Welcome to the NanoBiosensors and BioDevices Laboratory at IIT Kharagpur. We deploy a holistic engineering strategy combining biochemistry, nanomaterial synthesis, and advanced manufacturing to engineer scalable, industrial-ready solutions for diagnostic platforms.
Our goals target crucial socio-economic sectors by designing state-of-the-art non-invasive diagnostics tools, high-precision atmospheric telemetry arrays, and interactive, IoT-connected applications to decentralize and democratize precision screening.
Research Areas
Point-of-care Biosensors
Biosensors for on-site food quality monitoring, rapid healthcare diagnostic applications and environmental monitoring via IoT integrated user immersive smartphone apps.
Nanotechnology & Material Science
Enhancing complexation and interaction between biological and non-biological entities with nanomaterials/ composites for electrochemical quantification further improving sensitivity.
3D-Printing & Microfluidics
Developing devices to be used at the point-of-care to enable quick detection of different biomarkers with minimal fluid/sample processing required.
Molecular Design & In-Silico Studies
In-Silico designing and 3D-modelling of biological molecules and molecular dynamic simulations for enhancing biorecognition moiety of biosensors.
High-Precision Gas Sensing System
Cutting-edge gas sensing system designed for real-time and accurate detection of target gases. Utilizes advanced sensor technologies, ensuring high sensitivity and reliability for research and industrial applications.
Inside the Lab
Video Feature: Research Overview at IIT Kharagpur
Ongoing Projects
Completed Projects
Our Team
Our members are experts on inherently cross-disciplinary areas, combining biosensing, electrochemistry, healthcare, electronics, manufacturing, nanotechnology, and biomedical engineering.
Post Doctoral Fellow
Nanomaterials Based Biomedical Sensors
Doctoral Students
Fabrication of 3D Printed Microfluidics for Sensors and Biological Applications
Lab-on-a-Chip for food quality assurance and early disease diagnosis
Translating lab to market nano-biosensors and biorecognition molecules
Development of electrochemical biosensors for environmental monitoring
Development of nano-biosensor devices for biomarker detection
Development of Carbon Electrodes for Point-of-Care Applications
Current Master Project Students & Interns
Alumni
Kinetic studies of electrochemical signal amplification system and its application in biosensor
Previous Master Project Students & Interns
🤝 Industry Partners
Collaborating with industry leaders to translate innovative biosensor and biomedical technologies into real-world applications.
Research Funding & Projects
Overview of sponsored research initiatives, breakthrough biosensing technologies, and ongoing clinical/environmental validations.
Electrochemical Printed Chip Device for Next Generation Point-of-Care Disease Detection
Objective: To develop a fast-response within a short span of 10 minutes duration for single step Lab-on-a-chip biosensor platform to detect multiple disease biomarkers.
Noninvasive Electrochemical Patch Biosensor for Point-of-Care Monitoring of Skin Infection
Objective: To develop a low-cost disposable noninvasive printed chip based biosensor patch for psoriasin detection using label-free technique.
Non-enzymatic Microfluidic Electrochemical Multiplex Sensor for Cost-effective Soil Testing
Objective: Provide an enzyme-free multiplexed sensing device for rapid on-site detection of NO3- and organophosphates in soil, improving rural farming livelihoods.
Wash-free Electrochemical Lab-on-a-chip for Rheumatoid Arthritis Protein Markers
Objective: Early diagnostic simultaneous detection of multiple protein markers in women using label-free redox cycling based electrochemical immunosensors.
Developing a Water Quality Monitoring Device
Objective: Novel miniaturized, handy electrochemical lab-on-a-chip device to directly detect and quantify fluoride, nitrate, phosphate, and arsenic ion in ground water.
Fabrication of Wash-Free Electrochemical Aptasensor Device HEAT
Objective: Low-cost rapid surveillance of Hepatitis A & E virus using a portable IoT enabled potentiostat for remote validation without complex setups.
Rheumotron Moby: Validation & Marketing of Label-Free Biosensing Device
Objective: Scale and quantitatively validate whole-blood multi-biomarker detection panels (RF, Anti-CCP, CRP) for streamlined early Rheumatoid Arthritis tracking.
Smart Lab-on-a-chip for Salivary Oral Cancer Biomarkers & ML Modeling
Objective: Multiplexed biosensing of IL-8, sCD44, and PD-L1 linked to Machine Learning prognosis tools tracking clinical/histological attributes.
Point-of-Care Electrochemical Biosensor for Tuberculosis Detection
Objective: Develop rapid TB detection platform using antigen-antibody interactions on printed electrodes for resource-limited settings.
📚 Publications, Books & Patents
Research contributions including Journal Articles, Review Papers, Books, Book Chapters, Conference Proceedings and Intellectual Property.
- R. R. Suresh, G. Dutta*, Alkaline electrooxidation of urea on silver nanointerface: mechanistic insights and non-enzymatic sensing for onsite monitoring, Electrochimica Acta, 2026. IF: 5.6 DOI
- D. C. Patra, R. R. Suresh, C. Hazra, R. Dastidar, P. Sengupta, G. Dutta*, Point-of-Care Sodium Ion Detection Using Membrane-Free MnO₂ Nanoparticle Modified LIG Electrodes in Human Saliva, Biosensors and Bioelectronics: X, 2026. DOI
- R. R. Suresh, C. Hazra, R. Dastidar, P. Sengupta, G. Dutta*, Silver-dendrites Modified Laser Induced Graphene Electrodes as a Handheld Electrochemical Non-Enzymatic Sensor Device for Onsite Salivary Urea Detection, Biosensors and Bioelectronics: X, 2026. DOI
- D. C. Patra, R. R. Suresh, G. Dutta*, A potentiometric sensor based on porous ZnO nanorod-modified laser-induced graphene electrodes for point-of-care salivary potassium ion detection, Microchemical Journal, 2026. IF: 5.1 DOI
- B. Datta, R. R. Suresh, G. Dutta*, A portable electrochemical platform for biorecognition-free detection of ochratoxin A and ascorbic acid for food safety and quality monitoring, Analyst, 2026. IF: 3.3 DOI
- M. Mandal, M. Niki, B. Mukherjee, T. Samanta, G. Dutta*, A Cost-Effective Non-Enzymatic Electrochemical Multiplex Aptasensor Platform for On-Site Pesticide Detection, ACS ES&T Engineering, 2025. IF: 7.3 DOI
- P. Mukherjee, M. Mandal, B. Mukherjee, G. Dutta*, Nonenzymatic Electrochemical Sensor Device for On-Site Nitrate Determination Using Copper Anchored Magnetite Nanocomposites, Langmuir, 2025. IF: 3.7 DOI
- B. Mukherjee, M. Mandal, R.R. Suresh, S. Kar, B.K. Parida, S. Chakraborty, G. Dutta, A non-enzymatic highly stable electrochemical sensing platform based on allylamine capped copper nanoparticles for the detection of the soil nitrate content, Analyst, 2025. IF: 3.6 DOI
- B. Datta, B. Manasur, G. Sreelekha, P. Verma, C. Adak, R. P. Shukla, G. Dutta*, Quantification of L-lactic acid in human plasma samples using Ni-based electrodes and machine learning approach, Talanta, 2025, 286, 127493. IF: 5.6 DOI
- S. Verma, A. Sen, N. Dutta, P. Sengupta, P. Chakraborty, G. Dutta*, Highly Specific Non-Enzymatic Electrochemical Sensor for the Detection of Uric Acid Using Carboxylated Multiwalled Carbon Nanotubes Intertwined with GdS-Gd₂O₃ Nanoplates in Human Urine and Serum, Langmuir, 2024, 40, 21427-21441. IF: 3.7 DOI
- N. Dutta, R.R Suresh, G. Dutta*, Adsorption-controlled electrochemical reaction with reversible dimerization, coupled to a preceding chemical reaction on porous graphenic surface: Modelling and application in label-free capacitive biosensing, Journal of Electroanalytical Chemistry, 2024, 118540. IF: 4.1 DOI
- S. Vishnu, S. Maity, A. C Maity, M. S Kumar, M. Dolai, A. Nag, Y. Bylappa, G. Dutta, B. Mukherjee, A. Das, Development of a fluorescent scaffold by utilizing quercetin template for selective detection of Hg²⁺: Experimental and theoretical studies along with live cell imaging, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2024, 315, 124249. IF: 4.3 DOI
- P. Biswas, A. Mukherjee, P. Goyal, P. Bhattacharya, G. Dutta*, S. Chakraborty, A rapid diagnostic technology for isolating rare blood group patients under medical emergency using a three-fold paper-polymer microfluidic kit, Sensors and Actuators B: Chemical, 2024, 409, 135650. IF: 8.0 DOI
- Ashish, P. Biswas, B. Datta, C. Kanike, A. Atta, G. Dutta*, A study on the dynamics of bacterial growth using biocompatible 3D-printed microfluidic device, Chemical Engineering Journal, 2024, 493, 152687. IF: 13.3 DOI
- R.R Suresh, G. Dutta*, Tailoring the pore accessibility using proteins in laser induced porous graphitic structures: Correlating the physicochemical & electrochemical characteristics, Electrochimica Acta, 2024, 483, 144027. IF: 5.5 DOI
- R. Jain, S. Verma, G. Dutta*, A Machine Learning-based approach for Simultaneous Detection of Interfering Analytes in Electrochemical Nanobiosensors, bioRxiv, 2024. DOI
- B. Datta, P. Bhatt, G. Dutta*, A Redox Mediator-Free Highly Selective and Sensitive Electrochemical Aptasensor for Patulin Mycotoxin Detection in Apple Juice Using Ni–NiO Pseudocapacitive Nanomaterials, Journal of Agricultural and Food Chemistry, 2024, 72, 5993-6005. IF: 5.7 DOI
- N. Pandey, M. Mandal, D. Samanta, G. Mukherjee, G. Dutta*, A nanobody based ultrasensitive electrochemical biosensor for the detection of soluble CTLA-4–A candidate biomarker for cancer development and progression, Biosensors and Bioelectronics, 2023, 242, 115733. IF: 10.7 DOI
- T. Sarkar, N. Dutta, G. Dutta*, A new biosensing platform based on L-cysteine-capped Fe₃O₄ nanoparticles embedded in chitosan-MWCNT matrix: Electrochemical kinetic and sensing studies, Biosensors and Bioelectronics: X, 2023, 15, 100412. DOI
- S. Sinha, A. Basu, J. Shukla, S. Dasgupta, G. Dutta, S. Das, A smartphone-integrated low-cost, reagent-free, non-destructive dried blood spot-based paper sensor for hematocrit measurement, Analytical Methods, 2023, 15, 3532-3542. IF: 2.7 DOI
- N. P Rao, M. S Kumar, S. Vishnu, B. Mukherjee, N. Karthik, G. Dutta, A.K Das, A fast survey on recent developments in designing colorimetric and fluorescent sensors for the selective detection of essential amino acids, Analytical Methods, 2023, 15, 2546-2577. IF: 2.7 DOI
- P. Choudhury, S. Biswas, G. Singh, A. Pal, N. Ghosh, A.K. Ojha, S. Das, G. Dutta, K. Chaudhury, Immunological profiling and development of a sensing device for detection of IL-13 in COPD and asthma, Bioelectrochemistry, 2022, 143, 107971. IF: 5.373 DOI
- S. Liu, A. Ay, Q. Luo, X. Hu, K. Białas, G. Dutta, D. Moschou, A. Regoutz, Oxidation of copper electrodes on flexible polyimide substrates for non-enzymatic glucose sensing, Materials Research Express, 2022, 9, 045010. IF: 1.99 DOI
- S. Chattopadhyay, R. Ram, A. Sarkar, G. Dutta, & S. Chakraborty, Reagent-free Hemoglobin Estimation on a Spinning Disc, Microchemical Journal, 2021, 168, 106463. IF: 3.594 DOI
- G. Dutta, F.C.B. Fernandes, P. Estrela, D. Moschou, P. R. Bueno, Impact of surface roughness on the self-assembling of molecular films onto gold electrodes for label-free biosensing applications, Electrochimica Acta, 2021, 378, 138137. IF: 6.215 DOI
- G. Dutta, A. Regoutz, D. Moschou, Enzyme-assisted glucose quantification for a painless Lab-on-PCB patch implementation, Biosensors and Bioelectronics, 2020, 167, 112484. IF: 10.257 DOI
- A. Paul, N. Dutta, D. Moschou, G. Dutta*, Advanced integrative sensing technologies for detection of drug-resistant tuberculosis in point-of-care settings, Sensors International, 2020, 1, 100036. DOI
- G. Dutta*, A. Jallow, D. Paul, & D. Moschou, Label-free electrochemical detection of S. mutans exploiting commercially fabricated printed circuit board sensing electrodes, Micromachines, 2019, 10, 575. IF: 2.5 DOI
- G. Dutta, P. B. Lillehoj, Wash-free, label-free immunoassay for rapid electrochemical detection of PfHRP2 in whole blood samples, Scientific Reports, 2018, 8, 17129. IF: 4.122 DOI
- G. Dutta, S. Nagarajan, L. J. Lapidus, P. B. Lillehoj, Enzyme-free electrochemical immunosensor based on methylene blue and the electro-oxidation of hydrazine on Pt nanoparticles, Biosensors and Bioelectronics, 2017, 92, 372–377. IF: 10.257 DOI
- G. Dutta, P. B. Lillehoj, An ultrasensitive enzyme-free electrochemical immunosensor based on redox cycling amplification using methylene blue, Analyst, 2017, 142, 3492-3499. IF: 3.906 DOI
- G. Dutta, H. Yang, Effects of aging on electrocatalytic activities of pt and pd nanoparticles, Journal of Electrochemical Science and Technology, 2016, 7, 27-32. IF: 0.972 DOI
- K. Das, S. Goswami, G. Dutta, S. Maity, T. K. Mandal, K. Khanra, N. Bhattacharyya, Concentration dependent relay-recognition by same analyte: Dual fluorescence switch-on by hydrogen sulfide via Michael addition followed by reduction and staining bio-activity, Organic & Biomolecular Chemistry, 2016, 14, 570-576. IF: 3.564 DOI
- G. Dutta, S. Park, A. Singh, J. Seo, S. Kim, H. Yang, Low-interference washing-free electrochemical immunosensor using glycerol-3-phosphate dehydrogenase as an enzyme label, Analytical Chemistry, 2015, 87, 3574-3578. IF: 6.320 DOI
- A.-M. J. Haque, J. Kim, G. Dutta, S. Kim, H. Yang, Redox cycling-amplified enzymatic Ag deposition and its application in highly sensitive detection of creatine kinase-MB, Chemical Communication, 2015, 51, 14493-14496. IF: 6.834 DOI
- S. Park, J. Kim, H. Ock, G. Dutta, E-C. Shin, H. Yang, Sensitive electrochemical detection of vaccinia virus in a solution containing a high concentration of L-ascorbic acid, Analyst, 2015, 140, 5481-5487. IF: 3.906 DOI
- G. Dutta, A.M.J. Haque & H.Yang, Improvement of the electrocatalytic activities of long-aged Pt electrodes and the change of the improved activities with aging, Electrochimica Acta, 2014, 141, 319-323. IF: 4.803 DOI
- G. Dutta, S. Kim, S. Park, & H. Yang, Washing-free heterogeneous immunosensor using proximity-dependent electron mediation between an enzyme label and an electrode, Analytical Chemistry, 2014, 86(9), 4589-4595. IF: 6.320 DOI
- G. Dutta, Jo, K., Lee, H., Kim, B., H. Y. Woo, & H. Yang, Time-dependent decrease in the enhanced electrocatalytic activities observed after three different pretreatments of gold electrodes, Journal of Electroanalytical Chemistry, 2012, 675, 41-46. IF: 3.807 DOI
- K. Jo, G. Dutta, J. W. Kim, & H.Yang, Facile decrease in the electron-transfer rate and surface roughness of gold by ultrasonic treatment, Chemical Communications, 2012, 48(70), 8841-8843. IF: 5.996 DOI
- G. Dutta, & H. Yang, Effect of Fenton's reagent on the electrocatalytic activity of gold nanoparticles, Electrochemistry Communications, 2011, 13(12), 1328-1331. IF: 4.333 DOI
- G. Dutta, R. K. Debnath, A. Kalita, P. Kumar, M. Sarma, R. B. Shankar, & B. Mondal, An asymmetric dinuclear copper (II) complex with phenoxo and acetate bridges: Synthesis, structure and magnetic studies, Polyhedron, 2011, 30(2), 293-298. IF: 2.343 DOI
N. Pandey, D. Biswas, N. Dutta, A. Hansda, G. Dutta, G. Mukherjee, Sensing Soluble Immune Checkpoint Molecules and Disease-Relevant Cytokines in Cancer: A Novel Paradigm in Disease Diagnosis and Monitoring, Frontiers in Sensors, 2022. DOI: 10.3389/fsens.2022.789771
M. Mandal, N. Dutta, G. Dutta*, Aptamer-based biosensors and their implications in COVID-19 diagnosis, Analytical Methods 13 (45), 5400-5417. DOI: 10.1039/D1AY01519B
S. Sahu, G. Dutta*, Emerging evidence for serum procalcitonin estimation at point-of-care and advancement in quantitative sensing strategies over the past decade, Sensors International, 2021, 2, 100107. DOI: 10.1016/j.sintl.2021.100107
N. Dutta, P.B. Lillehoj, P. Estrela, G. Dutta*, Electrochemical Biosensors for Cytokine Profiling: Recent Advancements and Possibilities in the Near Future, Biosensors, 2021, 11, 94. DOI: 10.3390/bios11030094
R. Mandal, G. Dutta*, From photosynthesis to biosensing: Chlorophyll proves to be a versatile molecule, Sensors International, 2020, 1, 100058. DOI: 10.1016/j.sintl.2020.100058
G. Dutta*, Electrochemical biosensors for rapid detection of malaria, Materials Science for Energy Technologies, 2020 3, 150-158. DOI: 10.1016/j.mset.2019.10.003
G. Dutta, J. Rainbow, U. Zupancic, S. Papamatthaiou, P. Estrela, D. Moschou, Microfluidic devices for label-free DNA detection, Chemosensors, 2018, 6, 43. DOI: 10.3390/chemosensors6040043
G. Dutta*, Wash-Free Redox Cycling Based Electrochemical Biosensors for Point-of-Care Diagnostic Applications, Biomedical Journal of Scientific & Technical Research, 2018, 10(3), 7845-7847.
IntechOpen. ISBN 978-1-80356-963-5
Editor: Dr. Soumen Dhara, Dr. Gorachand Dutta
Springer Nature Publication. ISBN 978-981-19-8713-7
Editor: Dr. Koushik Guha, Dr. Gorachand Dutta, Dr. Arindam Biswas, Dr. K Srinivasa Rao
Springer Publication. ISBN 978-981-19-7129-7
Editor: Dr. Gorachand Dutta
Springer Publication. ISBN 978-981-19-7106-8
Editor: Dr. Gorachand Dutta, Dr. Arindam Biswas
CRC Press Taylor & Francis Group. ISBN 978-0-367-60888-0
Authors: S. K. Chaurasiya, J. Dutta, A. Biswas, Gorachand Dutta, M. K. Sarkar
Springer Publication. ISBN 978-981-15-9612-4
Editor: Dr. Gorachand Dutta, Dr. Arindam Biswas, Dr. Amlan Chakrabarti
- “Lab-On-Chip Electrochemical Biosensor for Rheumatoid Arthritis”. (2023) in MEMS and Microfluidics in Healthcare: Devices and Applications Perspectives (pp. 157-181). Springer Nature Singapore.
- “Role of Biosensors in Regenerative Therapeutics: Past, Present, and Future Prospect”. (2023) in Regenerative Medicine: Emerging Techniques to Translation Approaches (pp. 77-95). Springer Nature Singapore.
- “Fabrication of Blue Laser-Induced Graphene Electrodes and Evaluation of Their Electroanalytical Performance”. (2023) in Micro and Nanoelectronics Devices, Circuits and Systems (pp. 241-249). Springer Nature Singapore.
- “Electrochemical Detection of Cancer Fingerprint: A Systematic Review on Recent Progress in Extracellular Vesicle Research from Lab to Market”. (2022) in Next-Generation Nanobiosensor Devices for Point-Of-Care Diagnostics (pp. 47-77). Springer Nature Singapore.
- “Machine learning-enabled biosensors in clinical decision making”. (2022) in Next-Generation Nanobiosensor Devices for Point-Of-Care Diagnostics (pp. 163-194). Springer Nature Singapore.
- “Application of Radiopharmaceuticals in Diagnostics and Therapy”. (2022) in Next-Generation Nanobiosensor Devices for Point-Of-Care Diagnostics (pp. 227-249). Springer Nature Singapore.
- “Electrochemical biosensor designs used for detecting SARS-CoV-2 virus: A review”. (2022) in Next Generation Smart Nano-Bio-Devices (pp. 187-209). Springer Nature Singapore.
- “Antibody-Based Sensors for Pathogen Detection”. (2022) in Protocols for the Diagnosis of Pig Viral Diseases (pp. 171-193). Humana, New York, NY.
- “Current Methods and Future of Tuberculosis (TB) Diagnosis”. (2021) in Modern Techniques in Biosensors (pp. 163-182). Springer, Singapore.
- “Redox Cycling Technologies for Point-of-Care Immunodiagnostics in Various Matrices” (Invited). (2021) in Immunodiagnostic Technologies from Laboratory to Point-Of-Care Testing (pp. 75-91). Springer, Singapore. Link
- “Nanobiosensors Based Diagnostics System: Transducers and Surface Materials” (Invited). (2020) in Nanobiomaterial Engineering (pp. 1-13). Springer, Singapore. DOI
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Dr. Gorachand Dutta
Assistant Professor – Grade-I
School of Medical Science and Technology (SMST)
Indian Institute of Technology Kharagpur